MOTS-C

MOTS-C — Mitochondrial Metabolic Research Peptide

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial genome. It has been widely explored in preclinical research for its role in cellular metabolism, mitochondrial signaling, metabolic homeostasis, and adaptive responses to cellular stress. MOTS-C has gained particular research interest for its relationship with skeletal muscle metabolism and pathways involved in cellular energy regulation.

Mechanism of Action

MOTS-C has been studied for its influence on cellular metabolic pathways, particularly those involving AMP-activated protein kinase (AMPK), an important regulator of cellular energy balance. Research indicates that MOTS-C can influence the folate-methionine cycle and de novo purine biosynthesis, resulting in increased levels of the metabolic intermediate AICAR and subsequent activation of AMPK.

Research models have also demonstrated effects involving glucose utilization, fatty-acid metabolism, insulin signaling, and skeletal muscle function. These mechanisms have made MOTS-C an important research compound for investigating mitochondrial communication, cellular energy regulation, metabolic adaptation, and age-associated changes in cellular function.

Research Applications

• Mitochondrial function and signaling studies
• Cellular energy metabolism research
• AMPK signaling pathway investigations
• Glucose utilization and metabolic homeostasis studies
• Skeletal muscle metabolism research
• Insulin signaling and sensitivity research models
• Cellular stress and metabolic adaptation studies
• Aging and mitochondrial biology research

Product Specifications

• Quantity: 40 mg per vial
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested in the USA, COA available

Intended for laboratory research use only. Not for human consumption or therapeutic use.